Seachem Cupramine 50 ml – 250 ml




Cupramine™ effectively eradicates Oodinium, Cryptocaryon, Amyloodinium, Ichthyophthirius, and other ectoparasites of both freshwater and marine fish. It is superior to copper sulfate, chloride & citrate: it is non-acidic, less toxic to fish, remains in solution, and does not contaminate the filter bed. It is superior to chelates: it is fully charged (ionic), active at low concentrations, and is removable with carbon.

There is more than a four-fold concentration gap between the minimal therapeutic dose (0.2 mg/L) and the toxic dose (0.8 mg/L). Cupramine™ is easily removable with chemical filtration. It is highly effective and safe in freshwater as well as marine water.

Cupramine™ is appropriate for treating a variety of ectoparasites of both freshwater and marine fish. Below are some of the more common infections treatable with Cupramine™. Be aware that many diseases and infections share similar physical and behavioral symptoms, e.g. clamped fins, lesions, loss of appetite.

Before Treatment:

Remove all invertebrates as these organisms are extremely sensitive to copper and may become sick or worse with a copper-based medication. Turn off any UV filters, ozone filters, and remove all chemical filtration like MatrixCarbon and Purigen. Do not use this formula in conjunction with any other medication. Do not use products that contain reducing agents (conditioners, ammonia binders, etc.) while using Cupramine.


If you have a bottle with a dropper cap, use exactly 20 drops (1 mL) per 40 L (10.5 US gallons) the first day, wait 48 hours and then repeat this process. On non-dropper caps, each inner ring is equivalent to 1 mL. In freshwater aquariums use only a half dose. The final copper concentration is 0.5 mg/L (0.25 mg/L in freshwater). Leave the aquarium at this concentration for 14 days. Do not redose without testing (MultiTest Copper). If tank has ever been treated with an ionic copper (e.g. copper chloride, sulfate or citrate), test copper level after initial dosing. Although most fish tolerate Cupramine to 0.8 mg/L, it is not advisable to exceed 0.6 mg/L copper.

Finishing the Full Treatment:

Ich, velvet, and many other common parasites spend a large portion of their life cycle as a small cyst that hides in the substrate of your tank and is immune to medication. Because of this, it is VERY important that you finish the full treatment even if you can’t see any more parasites on the fish!

After Treatment:

Cupramine can be removed using carbon or Seachem CupriSorb. You can leave the copper-absorbing media inside of your aquarium for at least a week after the copper concentration has reached 0 to ensure that all traces of the medication have been removed entirely.


  • Copper treatment for external parasites
  • Active at low concentration (does not precipitate)
  • Bound on amine so it is not as toxic to fish
  • 100% Removable with carbon or Cuprisorb
© 2021 Northeast Brine Shrimp, LLC